Friday, November 5, 2021

Fighting lethal cancer with knowledge, spirit, strength confidence


 I've never been in low spirits

Intelligence, confidence, the strength of spirit

Never been dispirited: deprived of spirit, hope, enthusiasm

While crossing the deep chasm

Living in a fractured World 

Invigorating effect on my body and my spirits

But O, sick people of the world,

Are always hurled

Forget your troubles and let your woes lay

And when again there's morning they'll wash away

Put me in a gale of laughter spirits will rise more

There was the shrieking  of a door

 Being torn from its rusty, creaky hinges

Anything worth dying for is certainly worth living for

That I am  here--- that life exists,

 And identity, that the powerful play goes on

The meanness of spirit, slowness of intelligence

I was not sick of any fear from thence

My best defense is belligerence

All dumb arrogance 

In a soup of anger, frustration ,fear

Without broadcasting it


Feel so good to say

A deeper sense of satisfaction

PRRT is recommended for patients who have somatostatin receptor-positive


Vibes I got from medical folksies so  negative 

As a matter of fact that sound the opposite

If you don't have a stable but progressive NET cancer

As I qualify for PRRT thats my  best answer

To win the War.


 Receiving a dose of amino acid solution through an IV to protect the kidneys from radiation

Like chemotherapy it's not a tradition.

 By reducing how much radiation they absorb. 

They don't blunder, bungle or poorly perform


Then, octreotide, a synthetic cell-targeting protein, or peptide, 

Life has been ebb and tide


Neuroendocrine tumors (NETs) are neoplasms derived from nerve and endocrine cells.

Hippocrates is often credited with developing the theory of the four humorsm

blood, yellow bile, black bile, and phlegm—and their influence on the body and its emotions.

NETs have the ability to produce hormones and have similarities with nerve cells, 

NETs were called “carcinoid” 100 years ago and were considered benign neoplasms. 

Metastatic disease is a major prognostic factor in neuroendocrine neoplasms

 in addition to differentiation and proliferation rate 

Currently they are considered to be malignant, WHO's histopathological classification eliminated the “carcinoid” label in 2000.

In the WHO classification of 2010, NETs were defined as neuroendocrine neoplasms and were classified as NET G1, NET G2, NEC (large cell or small cell type), mixed adeno neuroendocrine carcinoma (MANEC), hyperplastic, and preneoplastic lesions, by the Ki-67 index.

NETs are increasing and are therefore attracting interest and attention.

Generally, the majority of metastases occur in the liver, lungs, and bone.

As during acidity they shone

Other sites are rarer, and brain metastases are very rare.

Here we present a probable primary brain NET. To knowledge, this is the first reported case of a primary NET arising in that anatomical location.

Brain metastases (BM) are rarely reported in patients with neuroendocrine carcinoma (NEC) of non-lung origin and neuroendocrine tumors (NET) of the gastro enteropancreatic (GEP) or bronchopulmonary system.

Nobody ever miss'd them.

But her tight fisted mastery and ego missed them


 However, symptomatic brain metastases are associated with dismal prognosis, so early detection and treatment could be advisable


In almost all cases, the presence of BM was a characteristic of a systemic dissemination
 And disease progression.

Symptomatic brain metastases are associated with dismal prognosis, so early detection and treatment could be advisable


Proteins are made of amino acids arranged in a linear chain joined together by bonds of peptide

 Is combined with a small amount of radioactive material,

Or radionuclide, to create a radiopeptide.


When the radiopeptide is injected into a patient’s bloodstream, it binds to protein receptors called somatostatin receptors, located on NET cells,

Delivers high doses of radiation to the tumor. Because it’s a systemic treatment,

Like lock and key they tell

She isn't a doctor who's halfway decent

PRRT targets NETs with somatostatin receptors anywhere in the body.

Her work has always been shoddy


The amino acid solution is also delivered to PRRT patients Post radiopeptide injection.

For years some practiced practiced at the art of deception

Because small amounts of radiation may remain in the body, patients are generally advised to take certain precautions after treatment, especially for the first one to two days.


NETs that cannot be removed with surgery

 Are typically treated with hormone therapy 

to control symptoms and tumor growth. 

But in cases when tumors continue to grow despite treatment,

Would use PRRT who's halfway decent

Use of contrast agents has resulted in reduced radiation, while maintaining image quality. 

"If you want my advice or support..you cannot dictate what test or scan I do and how"

"You want to get any test you want..pay for it and get it done wherever you want"
Well, I say you can't indemnify the loss to my health 
Ma'am Director of Nuclear Medicine at FMRI just concerned about power, wealth, rank 
Momma you stank
Wise yourself up
Instead of talking pointedly

Primary well-differentiated neuroendocrine tumors arising in the intracranial portion of the central nervous system (CNS) are occasional findings.

 


On the other hand, the CNS more frequently represents a metastatic site for primary poorly differentiated NET arising elsewhere, most often in the lung (small-cell lung cancer) .

In such cases, other secondary lesions, such as liver, lung and lymph nodes metastases, are often detected synchronously or metachronously with CNS localizations.


Patients with brain metastases are rare;

"Payal...there are many centres offering PRRT..please go to them. I will never do what I am not convinced will help my patient."-- don't prefer tyrant 


You define them as you call this one ignorant

Thinking they are the masters under the illusion of wealth, 

Facts are superior to lies,

Conflict between science and ethics

And lies cannot cover up facts

 Desired superiority thinking of attainments

Calcifications are visible within the necrotic areas of a tumor nest

My spleen isn't a jest


Neuroendocrine differentiation was confirmed using the following immunohistochemical markers: 

Chromogranin, synaptophysin and neural cell adhesion molecule.  

 With one study reporting a median survival time of 10.0 months after diagnosis of brain metastases 

Overall, brain metastases occur in 1.5–6% and their detection is usually preceded by the documentation of the primary, extracranial tumor 


Nevertheless, neuroendocrine markers have been found to be overexpressed in rare oral neuroendocrine tumors, 

But also in quite common inflammatory conditions, such as severe periodontitis. 


The monitoring of neuroendocrine markers is, thus, a common factor of interest among dentistry and neurology: the analysis of neuroendocrine markers in oral diseases may be predictive and prognostic about the severity of neurological ailments


There are only a few reports to suggest NENs originating primarily from the brain. Neuroendocrine cells are naturally involved in the coordination of neurotransmitter-initiated synthesis and release of biologically active substances.

Therefore, NENs possess unique properties such as secreting physiologically active amines and peptidyl hormones which allow NENs to retain unique methods for identification


People are too complicated to be figured out objectively, plus they are known to change their minds! 

When you hear hoofbeats, think of horses not zebras

The wrongness of the moment

So frivolous, so ridiculous!

Gotten more out of life!




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