Viruses live in a twilight zone, somewhere between life
And its ingredients.
With a potential
Their growth is exponential
Are viruses alive?
Are viruses the fourth domain of life?
Where do viruses fit on this “tree” of life?
Residing in separate domain of life
However, viruses can infect all other forms of life
Virus genes are everywhere, merged into the genomes of all organisms
Viruses cannot generate their own energy
They can put host in jeopardy
They cannot grow or propagate
They evolve and mutate
Depending on cells they have the key to infect
As they detect
To survive use their mechanism
Have power to bring cataclysm
Teetering on the boundaries of what is considered life
Containing the key elements that make up all living organisms: the nucleic acids, DNA or RNA
What defines life?
Viruses face constant pressure from immune systems,
With multiple tactics to block their entrance
The trusted troops disarm and kill them when they manage to get In and stop them to enhance
Transmission from host to host is such a basic need
Deepest deathless need
For infectious agents that some take it a step further.
To increase their number
Contemplating the origins of life fascinates
Understanding the evolutionary history of viruses may shed some light
No clear explanation for the origin of viruses exist
Viruses may have arisen from mobile genetic elements
Gaining the ability to move between cells.
Hence adapted a parasitic replication strategy.
Twisted into a tragedy
Viruses existed before, and led to the evolution of, cellular life.
Continuing studies may provide clearer answers.
Or future studies may reveal that the answer
Is even murkier than it now appears.
Wuhan Institute of Virology was upgraded to the National Biosafety Laboratory :Level 4
Lab was involved in the research of coronaviruses
The causative agents of the severe acute respiratory syndrome: SARS outbreak
So be wise of the on your take
South China University pointed out that the intermediate host
Enhancing at most
The horseshoe bat was not available in the wet market
and did not live in the Wuhan territory
The only place the bats existed in the locality was the research facility
Which is just about 100 yards from the Wuhan wet market.
The horseshoe bats are found only in Yunnan district.
However, they are neither consumed as food in the city, nor are they ever traded in the markets.
The paper also states that in the Wuhan Center for Disease Control and Prevention located 280 m from the market,
The extraction and sequencing of the DNA and RNA from caged animals could have been a potential source of the pathogen.
The world was to see death of many people due to the antigen
Species of bats acting as natural reservoirs
For SARS-like CoVs (SL-CoVs),
Points out the genetic diversity of the viruses in bats,
Highlighting the possibility
Of infecting the humans.
As the pools of CoVs in bats were limited,
Likelihood of a future emergence of this viral outbreak was never anticipated
Chimeric virus containing the SHC014 spike in a SARS-CoV backbone causes robust infections in both human airway cultures and mice
A warning was issued that the starting materials required
SARS-like emergent strains were already circulating
In animal reservoirs.
A research team in China that spent 5 years in the Shitou caves of Yunnan
Sampling from the bats issued a similar warning and raised alerts for a potential disease outbreak
Causing lots of heartache
By December 2019, the first cluster of cases of infection with a novel CoV was reported in China.
The origins of the epidemic were investigated.
The WIV published reports stating that s new strain of CoV had bats as the “probable” source estimated
All the studies of Shi Zheng Li, the lead WIV virologist
On bat-related CoVs were centered in Yunnan.
However, the outbreak occurred in Wuhan,
Which is almost 900 km from Yunnan
Samples of infected patients compared with those from the bats,
None of them matched
If not from bats, where did this novel strain of CoV come from?
The Government of China conducted an investigation
Reported a wildlife market, 10 miles away from the virology institution
as the epicenter.
The theory of lab origin gains credibility
From unrelated, but nevertheless solid and tangible facts seemingly
South China University pointed out
Intermediate host, the horseshoe bat
Not available in the wet market
Not living in the Wuhan district.
The only place the bats existed in the locality
Existing in the research facility,
Just about 100 yards from the Wuhan wet market.
The horseshoe bats are found only in Yunnan
However, they are neither consumed as food in the city, Nor ever traded in the markets
In the Wuhan Center for Disease Control and Prevention located 280 m from the market,
The extraction and sequencing of the DNA and RNA
From caged animals could have been a potential source
Human mind is very coarse
This center is also adjacent to the Union Hospital, where the first groups of doctors were infected during this epidemic.
Retracted novel CoV similar to the genetic sequences of human immunodeficiency virus (HIV) and Ebola.
A stunning cocktail like Coca cola
Unlikely for a virus to have acquired such unique insertion
Naturally in a short duration.
These artificially engineered modification
Were thought to increase the range of host cells
So it can infect and put the world in frustration
Now the virus in the stormy world dwells
Variation is intimately linked to their disease-causing potential.
We've got everything essential.
Paramount to the understanding of RNA viruses is the concept of quasispecies
This is nothing sham nothing quasi
Viral quasispecies is a population structure of viruses
With a large number of variant genomes.
Can sink humanity in their venom
Quasispecies result from high mutation probability
as mutants arise continually
Changing in relative frequency as viral replication and selection production.
First developed to describe the early replicons
Replicating from single origin of replication
Components of a primitive RNA world
devoid of DNA or proteins
By all means
Viral RNA load correlates with high levels of viral replication
Patients who developed late respiratory breakdown despite Disappearance of nasopharyngeal viral RNA
False representation leads to damnation
Whether viral RNA load in lung tissue,
Or a surrogate sample such as tracheal aspirate, mirrors the decline in nasopharyngeal shedding.
Nevertheless, severe manifestations might be immunologically mediated
Has obvious implications for the potential to use immune-modulatory therapies for this subset of patients.
This finding is consistent with recent reports
Of course, of course
Corticosteroids were beneficial for acute respiratory distress syndrome, and possibly those with COVID-19.
Why did I get Covid 19 despite voluntary isolation?
Ignorance prevails
“Ignoring isn't ignorance,
Ignorance requires guts, boldness
Gloat knowledge wisdom
Prancing dancing scatty smartie
Experts have also strongly suggested
Solely relying on testing as a safeguard
You can not expect to be a lifeguard
People making ‘lax’ and taking other safety measures
For thoughtless pleasures, taking delight in certain measures
Taking mask-wearing and social distancing lightly
Pass on infections to others harshly
Tests are a preventive measure and only effective
As long as you put in place other security measures
Blood tests at times are a good marker of inflammation
If out of fear and frustration
With knowledge of immunosuppression
Asks me to fall apart I lost heart
In desperate aloneness
The mask lifted
Out came hollowness
She's just a social climber
Spine-chiller
Worrying about death of spouse
Who came to care for my mother
Who is my caregiver
Told me die now,
From close proximity
"Holy cow!"
I could see the conspiracy,
The human tyranny,
My contemplations are of Time
Pieces of coin can change
Make violent and strange
The desire to attack superseded everything
Defendant spouse
As my C-reactive protein and the D dimer rose
Defending the demoniac strength
We are no longer in same wavelength
Commenting my daily titanic struggle
Being a Mere pawn on the chessboard of life
Ordained my death
With an easy breath
Blindness and ignorance, Will lead you nowhere,
Unless you are aware
Long lament of the discreet
The parallel lines shall never meet.
